The Patented Solid Solution for cfDNA Purification 
Patented Innovative Magnet / Sleeve Designs
Patent Pending Room Temperature Thin Film Protease



References & Helpful Links Regarding cell-free Cancer and NIPT

Recent Articles:

Quantitative Analysis of Circulating Cell-Free DNA for Correlation with Lung Cancer Survival:  A Systematic Review and Meta-Analysis

Journal of Thoracic Oncology Volume 12, Issue 1, January 2017, Pages 43-53   

Plasma cell-free DNA level and its integrity as biomarkers to distinguish non-small cell lung cancer from tuberculosis

Clinica Chimica Acta   Available online 4 November 2017

Myriad Applications of Circulating Cell-Free DNA in Precision Organ Transplant Monitoring

Annals of the American Thoracic Society   Vol. 14, No. Supplement_3 | Sep 01, 2017

Clinical utility of circulating cell-free DNA in advanced colorectal cancer

PLoS ONE 12(8): e0183949

The role of cell-free DNA in predicting colorectal cancer prognosis

Expert Review of Gastroenterology & Hepatology Vol. 0 , Iss. 0,0

Cell-Free Circulating DNA Integrity Based on Peripheral Blood as a Biomarker for Diagnosis of Cancer: A Systematic Review

Cell-Free DNA Promoter Hypermethylation as Blood-Based Markers for Pancreatic Adenocarcinoma

Ph.d.-serien for Det Sundhedsvidenskabelige Fakultet, Aalborg Universitet, DOI: 10.5278/

Advances in liquid biopsy 

AJCR(ISSN 2572-5769)

Tech times - Liquid Biopsy

MIT Technology Review - Liquid Biopsy


Web Sites with Useful General Information

NPR - National Public Radio - Information about Prenatal Genetic Testing

NHGRI - National Human Genome Research Institute - Circulating Tumor DNA

NIH Press Release regarding Circulating Tumor DNA

Tim Forshew - Excellent Lecture on the uses of ctDNA


Non-Invasive Prenatal Diagnosis (NIPT) with Cell Free Fetal DNA

Y M Dennis Lo, Noemi Corbetta, Paul F Chamberlain, Vik Rai, Ian L Sargent, Christopher W GRedman, James S Wainscoat (1997) 

Presence of fetal DNA in maternal plasma and serum. The Lancet, 350 • August 16, 1997 485-487Lo, E. S.; Lo, Y. M.; Hjelm, N. M.; Thilaganathan, B. (1998). 

Transfer of nucleated maternal cells into fetal circulation during the second trimester of pregnancy. British Journal of Haematology 100 (3): 605-606.Lo, Y. M., et al. (1999). 

Rapid clearance of fetal DNA from maternal plasma" American Journal of Human Genetics 64 (1): 218-224.

Cell Free Circulating Tumor (ctDNA) Cancer Applications

Schwarzenbach, H.; Hoon, D.S.; Pantel, K. Cell-free nucleic acids as biomarkers in cancer patients. Nat. Rev. Cancer 2011, 11, 426–437

Schwarzenbach, H.; Circulating nucleic acids as biomarkers in breast cancer, Breast Cancer Res. 2013; 15(5): 211

Goebel, G.; Zitt, M.; Zitt, M.; Müller, H.M. Circulating nucleic acids in plasma or serum (CNAPS) as prognostic and predictive markers in patients with solid neoplasias. Dis. Markers 2005, 21, 105–120.

Figg, W.D.; Reid, J. Monitor tumor burden with circulating tumor DNA. Cancer Biol. Ther. 2013, 14, 697–698.

Jin, D.; Xie, S.; Mo, Z.; Liang, Y.; Guo, B.; Yu, M. Circulating DNA-important biomarker of cancer. J. Mol. Biomarkers Diagn. 2012, doi:10.4172/2155-9929.S2-009

Gormally, E.; Caboux, E.; Vineis, P.; Hainaut, P. Circulating free DNA in plasma or serum as biomarker of carcinogenesis: Practical aspects and biological significance. Mutat. Res. 2007, 635, 105–117.

Holdenrieder, S.; Nagel, D.; Schalhorn, A.; Heinemann, V.; Wilkowski, R.; von Pawel, J.; Raith, H.; Feldmann, K.; Kremer, A.E.; Müller, S.; et al. Clinical relevance of circulating nucleosomes in cancer. Ann. N. Y. Acad. Sci. 2008, 1137, 180–189.

Beck, J.; Urnovitz, H.B.; Riggert, J.; Clerici, M.; Schütz, E. Profile of the circulating DNA in apparently healthy individuals. Clin. Chem. 2009, 55, 607–608.

Elshimali, Y; Khaddour, H; Sarkissyan, M; Wu, Y; Vadgama, J. The Clinical Utilization of Circulating Cell Free DNA (CCFDNA) in Blood of Cancer Patients Int. J. Mol. Sci. 2013, 14, 18925-18958.

Hong Yuen Wong and Ben Ho Park ,  Ann Transl Med. 2014 Jan; 2(1): 2.

E Crowley, F Di Nicolantonio, F Loupakis & A Bardelli ,  Nature Reviews Clinical Oncology 10, 472-484 (August 2013) |doi:10.1038/nrclinonc.2013.110